At about 6am, 10 search warrants were simultaneously issued in Wellington and Montefiores, in addition to another five associated warrants in Sydney.

Ten people were arrested, including seven men - a 44-year-old, a 34-year-old, 28-year-old, 29-year-old, 30-year-old, and two 37-year-olds - and three women - a 28-year-old, 23-year-old and 35-year-old.

Six men were also arrested in Sydney.

ALSO MAKING NEWS:

"We will allege this operation has resulted in the complete dismantling and smashing of a significant methamphetamine, MDMA and other drug syndicate in the Wellington sector," Acting Assistant Commissioner McKenna said.

He said the syndicate had far-reaching tentacles into the Central West, including in Bourke, Walgett, Cobar and some correctional centres.

"We've taken out drug runners, street level suppliers, medium level suppliers and 'kingpins' in Sydney," Acting Assistant Commissioner McKenna said.

He said as well as thanking all of the officers involved, he was grateful to the Wellington residents.

"The Wellington community I'd like to think will be joining us in celebrating what was a terrific result today in taking people who want to pedal these insidious drugs off the streets and into jail where they belong."

The arrests on Wednesday were the results of a 14 month investigation.

Assistant Commissioner McKenna reassured the public that the police do listen.

"A lot of the time they might think 'what are the police doing?' but we can't come out and tell you what we're doing. We have to work behind-the-scenes, we have to work covertly so we can get the true criminality of these people and put them before the courts," he said.

Further arrests are expected to be made.

Anyone with information is encouraged to call Dubbo Police on 6883 1599 or Crime Stoppers on 1800 333 000.