The Great Western Highway reopened about 2am on Saturday morning, 13 hours after Friday's five-car crash near Lithgow.
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Earlier
Two people are dead and around a dozen others injured in a holiday season tragedy following a horror five-car crash on Friday.
Emergency services are currently on scene at a serious multi-vehicle crash on the Great Western Highway.
About 12.50pm, December 29 emergency services responded to reports of a five-vehicle crash about 15km north of Lithgow.
Two people have been confirmed dead with approximately a dozen other people being treated by NSW Ambulance paramedics for various injuries.
At least two helicopters attended the scene. A Westpac Rescue chopper from Newcastle flew in, so too did the Toll Rescue helicopter from Orange. It has landed at the Westmead Hospital.
Officers from Chifley Police District have established a crime scene and are awaiting the arrival of specialist police.
The Great Western Highway is closed in both directions and is expected to remain a crime scene for a considerable amount of time. Motorists are urged to avoid the area.
Diversions
Westbound: Barton Ave, Pipers Flat Rd, Range Rd, Great Western Hwy.
Eastbound: Range Rd, Pipers Flat Rd, Barton Ave, Great Western Hwy,