Cargo, second on the ladder, will be at home to Eugowra, who they defeated 44-30 in round three.
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Eugowra, seventh, have improved, sitting four points out of the top five, which makes this game one they must win to keep in touch.
Cargo Blue Heelers playing at home pose a big obstacle for the Golden Eagles. Both sides know how important the win is to them.
Manildra Rhinos host Grenfell Goannas, fourth and fifth respectively, equal on 14 points. Grenfell won 36-28 in round three.
The Rhinos at home before a big vocal crowd will be hard to beat. However the Goannas have been on song, winning their last three games to get in the top five.
The Rhinos, lost two of their last three games to Trundle and Condobolin before winning 54-22 over Binalong.
Burrangong Bears host Canowindra Tigers, both coming off narrow loses to Cargo and Eugowra.
The Bears are improving, having pushed Cargo for the win last Saturday while the Tigers are coming off a 28-26 loss to Eugowra. The Tigers know how important the win is and the points on the ladder.
In Saturday games, Condobolin will continue their winning run over Binalong Brahmans.
Competition leaders Trundle Boomers take on Peak hill in another western derby, which will be played at Tullamore.
Trundle will be hurting after going down to Condobolin last week.
In Youth League Condobolin take on Binalong, Manildra plays Grenfell and Trundle has the bye.
In League Tag Condobolin plays Binalong, Trundle plays Peak Hill, Cargo plays Eugowra, Burrangong plays Canowindra and Manildra plays Grenfell.