Around 200 firefighters from across the Central West have signed up for one of the most gruelling fundraisers going around.

The Firies Climb for Motor Neurone Disease, on Saturday, November 9, is tough and it involves firefighters wearing an oxygen mask, their heavy structural firefighting gear and air cylinder on their back and then racing to the top of Sydney Tower.

READ ALSO: Mazda faces legal action over car faults

This quickest time anyone has ever done this climb is a staggering 11 minutes.

"It's so hard that firefighters will lose one to three kilograms of body weight just doing the climb and that's all through sweating," event co-ordinator Keven Verhoeven said.

All up there's more than 600 entrants this year and they have come from across Australia as well as New Zealand, Japan and the United States.

The climb is open to all firefighting services - paid and volunteer.

Motor Neurone Disease (MND) is a progressive, terminal neurological disease. There is no known treatment or cure.

This will be the fourth time Mr Verhoeven, who also happens to be a firefighter with Oberon Fire and Rescue NSW, has competed in the climb.

"It's tough going, it's hard but not as hard as suffering through motor neurone disease," he said.

READ ALSO: 4WD owner sought over 50 dead turtles

Now in its fifth year the event has raised more than $2 million for the Macquarie University's Centre for Motor Neurone Disease Research.

"One hundred per cent of the funds raised from the climb go to this," Mr Verhoeven said.

The centre receives no federal or state funding to operate and is completely run through the support of public donations and research grants.

So far this year more than $475,000 has been raised, and it's not too late to donate to the cause or to a firefighter in this region.

"I would like to crack the 15 minute mark," Lithgow firefighter says of climb

If these Blayney firefighters can raise $15,000 they'll do it again next year

Doing the 'Full Monty' to raise funds for the climb in Cootamundra

One of the top fundraising teams is back from Gulgong

We train each Saturday wearing a 20 kilogram weight vest in Bathurst

The more money we can raise, the more chance there is of a cure, Nyngan firefighters say

Why not subscribe, the first 30 days of full website access is free.